Exelixis is committed to conducting business in a way that respects our environment and the Earth’s changing climate. We have already incorporated many environmentally sustainable practices into our facilities and operations, and we plan to incorporate more of these practices as we continue to grow As part of this commitment, Exelixis recognizes that climate change threatens human safety and well-being on a dramatic scale. We feel all businesses — especially those like ours that are dedicated to human health — have a duty to minimize their impact on climate change and promote a long and prosperous future for all of Earth’s inhabitants.Exelixis nurtures a culture where all employees feel empowered to be their authentic selves. We respect and appreciate each employee’s unique perspective and experiences, and believe that celebrating, encouraging and supporting both similarities and differences contributes to our company mission. As a socially responsible company, we include sustainability measures in our annual corporate goals that inform the compensation of our executive officers. Specifically for 2021 and 2022, we focused considerable resources on our human capital management strategy and DEI initiatives that are expanded upon in the following section. There is still work to be done, but we are proud of the progress we have made. We take pride in our core corporate values to Be Exceptional, Excel for Patients and Exceed Together, and remain committed to fostering a culture where each and every employee feels a sense of belonging to the Exelixis team and our mission.At Exelixis, we recognize that our company will not be successful in its mission to treat and defeat cancer unless we operate on a solid foundation of good governance, corporate responsibility and accountability. We embed strong legal and regulatory compliance practices and oversight into our scientific and business activities so that these activities will be conducted in a legal and ethical manner, and in the best interests of all Exelixis’ stakeholders. We have created and work to uphold a rigorous culture of compliance at every level of our organization so that we can safely and effectively deliver on our ongoing mission. The Nominating and Corporate Governance Committee (NCGC) of the Exelixis Board of Directors is responsible for reviewing and assessing the Company’s corporate sustainability strategy and policies, including with respect to ESG matters, and for overseeing management in its implementation of ESG efforts. The Board’s Compensation Committee has oversight of our policies and strategies related to human capital management including, but not limited to, recruiting, retention, career development and progressions, management succession planning (other than CEO succession), diversity and employment practices.The Ethics Committee and its reporting subcommittees facilitate dynamic risk management throughout the company by maintaining close supervision of each element of our business and driving insights through regular risk-based reporting. We supplement that reporting with periodic “deep- dive” assessments in areas of business operations identified as higher risk. To complete these assessments, we retain the services of outside experts or counsel, ensuring both appropriate expertise and sufficient objectivity are brought to the task of evaluating the effectiveness of the relevant operational activity and its level of legal and regulatory compliance.Our Code of Conduct reflects the values that drive the performance of our business operations and describes how our officers, directors, employees and contractors are expected to conduct themselves when representing Exelixis. The Code of Conduct also underscores our commitment to comply with laws that regulate our business activities as a biotechnology company. We expect all our employees to understand and abide by our Code of Conduct and other relevant policies that are essential to their daily duties and our business. Each employee is trained on, and reviews and acknowledges, these policies in their initial onboarding; they then undergo refresher training on an annual basis.